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Janus kinase (jak) inhibitors are a group of medicines that help block immune system signals in the body that can lead to swelling (inflammation) and pain in conditions like rheumatoid arthritis, ulcerative colitis, and psoriatic arthritis They work by blocking enzymes that lead to overactivity of the immune system Jak inhibitors come in oral and topical (skin) formulations In this article, learn about the dosage, uses, and ongoing research underway for jak inhibitors available in the united states, as well as common side effects, contraindications, and warnings It will also discuss promising jak inhibitors coming down the pipeline. Jak pairing patterns, their biologic effects, and jakis selectivity Jak pairing patterns associated with cytokine receptors (a), biological effects of the pathway (b) and selectivity of different jakis for each pathway (c) with higher numbers denoting lower selectivity Jak inhibitors like xeljanz, rinvoq, and opzelura can treat inflammatory conditions and even alopecia View this list of jak inhibitors to learn about their various uses. If you have rheumatoid arthritis (ra), your doctor may suggest janus kinase (jak) inhibitors to help ease your joint pain and swelling Janus kinase (jak) inhibitors, including tofacitinib, baricitinib, upadacitinib and filgotinib, are increasingly used in the treatment of rheumatoid arthritis (ra). Since members of the type i and type ii cytokine receptor families possess no catalytic kinase activity, they rely on the jak family of tyrosine kinases to phosphorylate and activate downstream proteins involved in their signal transduction pathways. A jak inhibitor interferes with signals in the body that are thought to cause inflammation This, in turn, reduces the inflammation that fuels diseases like eczema, psoriatic arthritis, and vitiligo.