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Excessive secretion of adh, causing water retention and dilution of blood, decreasing sodium concentration Siadh happens when your body makes excess amounts of antidiuretic hormone (adh) Siadh causes your body to retain too much water and commonly leads to hyponatremia, which is low levels of sodium in your blood. The syndrome of inappropriate secretion of antidiuretic hormone (siadh) is a disorder of impaired water excretion caused by the inability to suppress the secretion of. Pathogenesis and clinical malignancy (e.g Small cell lung cancer, head and neck cancer) tumor originates from neuroendocrine cells tumor acts as an ectopic site of adh production Syndrome of inappropriate antidiuresis (siad) is the most frequent cause of hypotonic hyponatremia, mediated by nonosmotic release of arginine vasopressin (avp, previously known as antidiuretic hormone), which acts on the renal v2 receptors to promote water retention. The syndrome of inappropriate antidiuretic hormone (siadh) is characterised by hypotonic hyponatraemia, concentrated urine, and a euvolaemic state The impairment of free water excretion is caused by increased arginine vasopressin (antidiuretic hormone or avp) release.